CSF choline and acetylcholinesterase in early-onset vs. late-onset Alzheimer's disease patients

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Abstract
Cerebrospinal fluid acetylcholinesterase (AChE) activity levels and choline (Ch) levels were studied in 52 dementia of Alzheimer type (DAT) patients and 20 age-matched controls. The AChE activity was significantly lower and Ch levels were significantly higher in DAT patients than the age-matched controls. There was no siginficant difference in AChE activity and Ch levels between early-onset (.ltoreq. 65 years) patients and late-onset (> 65 years) patients. However, the AChE activity was significantly lower in early-onset patients compared with age-matched controls but no difference was observed in late-onset patients compared with their age-matched controls. None of the biological measures (AChE, Ch) were significantly correlated with the degree of cognitive impairment, duration of the illness or the sex of these patients.