Cellular immunity to P. acnes in the normal population and patients with acne vulgaris

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Abstract
Patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to Propionibacterium acnes using a leukocyte migration inhibition test. Despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. When cellular immunity arises it is apparently a late event which may contribute to inflammation but is probably not a factor in its initiation.