THE DEGREE OF BONE MINERALIZATION IN HYPERTHYROIDISM ESTIMATED FROM THE PHOSPHORUS TO HYDROXYPROLINE RATIO IN BONE

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Abstract
The proportion between mineral and collagen in bone tissue, the degree of mineralization can be evaluated from the P to hydroxyproline ratio (P/Hypro ratio), determined in bone biopsies. The ratio was measured in 27 unselected hyperthyroid patients. No significant correlation was found between the P/Hypro ratio and the age of the patient, the duration of the disease or the value of serum thyroxine. The mean value of the P/Hypro ratio for the group studied was not significantly different from the normal mean. The results indicate a normal degree of mineralization in the bone of patients with hyperthyroidism.

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