THE ACTION OF INDORAMIN AND OTHER COMPOUNDS ON THE UPTAKE OF NEUROTRANSMITTERS INTO RAT CORTICAL SLICES
Open Access
- 19 July 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 51 (3) , 467-469
- https://doi.org/10.1111/j.1476-5381.1974.tb10687.x
Abstract
Indoramin has been tested for its ability to inhibit the uptake of tritiated (–)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other α-blocking agents and tricyclic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigatorsKeywords
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