EFFECTS OF HALOPEMIDE, A NEW PSYCHOTROPIC AGENT, ON THE UPTAKE OF SEROTONIN BY BLOOD-PLATELETS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 237  (2) , 267-274
Abstract
The influence of halopemide and some putative metabolites on [14C]-5-HT [5-hydroxytryptamine, serotonin] uptake into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 [1-[1-(2-aminoethyl)-4-piperidinyl]-5-chloro-1,3-dihydro-2H-benzimidazol-2-one dihydrobromide] and R 29676 [1-[4-piperidinyl]-5-chloro-1,3-dihydro-2H-benzimidazol-2-one] and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative halopemide metabolite, were totally devoid of activity.

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