Synthesis of (Z)- and (E)-9-[(2-Hydroxyethylidene)cyclopropyl]adenine—New Methylenecyclopropane Analogues of Adenosine and Their Substrate Activity for Adenosine Deaminase
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 19 (1-2) , 31-37
- https://doi.org/10.1080/15257770008032995
Abstract
Synthesis of Z- and E-methylenecyclopropane analogues of adenosine 3 and 4 by alkylation of adenine with novel alkylating agent 5 is described. The E-isomer 4 is a substrate for adenosine deaminase. Compounds 3 and 4 were tested for antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1.Keywords
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