Beta-adrenoreceptor mechanisms in essential tremor: a comparative single dose study of the effect of a non-selective and a beta-2 selective adrenoreceptor antagonist.

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Abstract
In order to study the mode of action of .beta.-adrenoceptor antagonists in essential tremor the efficacy of single oral doses of 2, 4 and 10 mg LI 32-468 (4-[3-tert-butylamino-2-hydroxy-propoxy)spiro[cyclohexan-1,2-indan]-1-one hydrogen malonate], a peripherally acting, selective .beta.-2 adrenoceptor antagonist, was compared with a single oral dose of 120 mg propranolol in a randomized, double blind, placebo controlled trial. Both the lowest dose of LI and propranolol were shown to be equally superior to placebo in attenuating tremor magnitude. The beneficial effect of .beta.-adrenoreceptor antagonists in essential tremor is mediated via peripheral .beta.-2 receptor mechanisms.