Formation of Vaccinia Virus DNA-Protein Complex in the presence of Isatin beta Thiosemicarbazone (IBT)
- 1 September 1978
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 40 (3) , 695-699
- https://doi.org/10.1099/0022-1317-40-3-695
Abstract
The association of newly synthesized vaccinia virus DNA with proteins in infected [human cervical carcinoma] HeLa cells was followed. A shift from a high density to a low density complex occurred between 3 and 6 h after infection. This process was not affected by isatin .beta. thiosemicarbazone (IBT), an inhibitor of poxvirus growth. At 22 h after infection in the absence of IBT, mature virions of high density were observed, but in the presence of the drug, high density DNA-protein complexes, which lack the 2 main virus core polypeptides, were formed.Keywords
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