A number of publications dealing with electrophoretic serum protein patterns and quantitative cerebrospinal fluid (C. S. F.) protein determinations of patients with various neurological diseases have appeared in the literature. However, most data have been confined to multiple sclerosis (M. S.) cases.* In our previous studies † of 43 patients with typical multiple sclerosis, simultaneous determinations of the serum and C. S. F. proteins were performed. Significant changes, based on group statistics, were found in the following electrophoretic serum protein fractions: decreased albumin and A/G ratio, increased α2- and β-globulins, with slightly elevated or normal γ-globulins (γ-G). Chemical analysis of the C. S. F. proteins ‡ disclosed statistically elevated γ-globulin and/or increased γ-globulin/total protein (γ-G/T. P.) ratios, in keeping with the finding of Kabat and associates.§ The combined protein changes in both serum and cerebrospinal fluid were termed by us the "protein profile." † It is well known that protein