Platelet–collagen interactions: membrane receptors and intracellular signalling pathways
- 24 December 1999
- journal article
- review article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 29 (12) , 1066-1076
- https://doi.org/10.1046/j.1365-2362.1999.00570.x
Abstract
Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet–collagen interaction support a ‘two-site, two-step’ model. Direct platelet binding to integrin α2β1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCγ2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.Keywords
This publication has 131 references indexed in Scilit:
- Activation of the GP IIb-IIIa Complex Induced by Platelet Adhesion to Collagen Is Mediated by Both α2β1 Integrin and GP VIJournal of Biological Chemistry, 1999
- Association of two silent polymorphisms of platelet glycoprotein la/lla receptor with risk of myocardial infarction: a case-control studyThe Lancet, 1999
- Fetal hemorrhage and platelet dysfunction in SLP-76–deficient miceJournal of Clinical Investigation, 1999
- The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and ConvulxinPublished by Elsevier ,1998
- Collagen-stimulated Activation of Syk but Not c-Src Is Severely Compromised in Human Platelets Lacking Membrane Glycoprotein VIPublished by Elsevier ,1997
- The use of collagen-based model peptides to investigate platelet-reactive sequences in collagenBiopolymers, 1996
- Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase InhibitorJournal of Biological Chemistry, 1996
- Collagen stimulates tyrosine phosphorylation of phospholipase C‐γ2 but not phospholipase C‐γ1 in human plateletsFEBS Letters, 1994
- Elevation of cAMP in Human Platelets Inhibits Thrombin-but Not Collagen-Induced Tyrosine PhosphorylationBiochemical and Biophysical Research Communications, 1993
- Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.The Journal of cell biology, 1993