"SLOW EPINEPHRINE"

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Abstract
Since the advent of protamine zinc insulin several years ago, efforts have been increased, I believe, toward the preparation of drugs which would be, when injected subcutaneously or intramuscularly, like protamine zinc insulin, piecemeal in action, slow in action, safer in action, and more efficient in action because of these qualities. Thus, no doubt, when Keenev1published his preliminary report in 193S on a "Slowly Absorbed Epinephrine Preparation" interest became more centered on epinephrine than before. Then a year later the same author2gave in detail his experiences with epinephrine in oil in twenty-four cases. The epinephrine in oil he used was a suspension of powdered epinephrine base in peanut oil. 1 cc. of the oil containing 2 mg. of epinephrine, or a 1:500 mixture. Pen patients who had had asthma, chronic in its manifestations, received relief from their symptoms of asthma for from eight to sixteen hours, while one patient received no prolonged effect from the doses that were indicated. Eleven others were treated during one or more acute paroxysms of asthma, remaining free from asthma for from nine to sixteen hours; one patient with urticaria and one patient with serum sickness secured evident relief from their symptoms for twelve hours. In comment as to the ill effects experienced from the drug, Keenev states that there may or may not he soreness, induration and swelling, with redness, at the points of injection and that frequent and consecutive injections may be irritating in the same fashion. However, the drug can be injected intramuscularly without producing a local reaction.

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