Pathogenic potential ofSchizophyllum communeisolated from a human case
- 1 January 1974
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 12 (2) , 233-244
- https://doi.org/10.1080/00362177485380311
Abstract
Schizophyllum commune, a basidiomycete, has been shown to be pathogenic for normal white Swiss mice inoculated intraperitoneally. Deaths occurred in suckling mice; weanling mice were more susceptible to infection than adults. Treatment with either cortisone or mucin or both did not alter the infection in adult mice, but cortisone did render the weanling mice much more susceptible, causing deaths in 75%. The fungus, isolated from human tissue, was shown to invade the lungs, lymph nodes, liver and subcutaneous tissue, producing subacute to granulomatous lesions. Cultures from these tissues were repeatedly positive and tissue sections showed penetration of the parenchyma by hyphae possessing clamp connections and sterigmata-like excretory organelles. El Schizopyllum commune es un basidiomiceto que ha demostrado ser patogénico para los ratones blancos por inoculación del IP. Ocurrieron muertes en ratones lactantes y los destetados fueron mas susceptibles a la infección que los adultos. El tratamiento con cortisona y/o con mucina no alteró la infección en los adultos pero la cortisona hizo que los destetados fueran mucho más susceptibles causando muertes en un 75% de ellos. El hongo, aislado del tejido humano, ha demostrado invadir los pulmones, los nódulos linfáticos, el hígado y tejidos subcutáneos produciendo lesiones, desde subagudas hasta granulomatosas. Los cultivos de estos tejidos fueron repetidamente positivos y los cortes de tejido demostraron penetración del parénquima por hifas que tienen “clamp connections” y órganos excretorios semejantes a las esterigmatas.Keywords
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