Comparative Hydrolysis of Certain Dental Local Anesthetics by Human Serum and Plasma
- 1 January 1961
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 40 (1) , 190-194
- https://doi.org/10.1177/00220345610400011201
Abstract
The results of comparative experiments with human serum show that acetylcholine chloride is hydrolyzed about 138 to 179, metabutethamine HC1 30 to 35, meprylcaine HC1 15 to 21, piperocaine HC1 5 to 8, and butethamine HC1 0.5 to 0.6 times faster than procaine HC1. An apparent overall parallelism exists between the rate of hydrolysis of acetylcholine and of the ester-type local anesthetics. In addition, divergent results obtained with respect to the effect of anticoagulants and of time suggest the existence of several cholinesterases having variable activity in regard to the hydrolysis of the ester-type local anesthetics.Keywords
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