Effect of nonprotein thiols in the intestinal tissue on the transport of salicylate.

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Abstract
Rat intestinal salicylate transport showed concentration dependency, especially up to 22.5 mM in the mucosal medium, in an experiment using in vitro everted rat intestinal sac prepared from jejunum, ileum and colon. Thus, it is suggested that both saturatable and unsaturatable transport processes are involved in the intestinal salicylate transport. However, it was also estimated that intestinal salicylate absorption at high concentration in the clinical therapeutic context occurred predominantly through the unsaturatable (passive) transport process. Only the saturatable transport process seems to be influenced by nonprotein thiol levels in the intestinal tissue; there was a decrease of salicylate transport with decrease of nonprotein thiols. Further, since the saturatable transport process was restored even by the exogenous nonprotein thiols such as cysteamine, a process of nonspecific binding to the mucosal membrane rather than a specific carrier system may be involved in the saturatable transport of salicylate.

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