Protection of Fungi against Polyene Antibiotics by Sterols

Abstract
A strain of Pseudomonas isolated by the enrichment culture technique with pyrrolidine as the sole C source has been found to catalyze the following reactions designated as [gamma] -aminobutyric-glutamic transaminase (reaction 1) and succinic semialdehyde dehydrogenase (reaction 2): [gamma] -Aminobutyrate + [gamma] -ketoglutarate5S succinic semialdehyde + glutamate (1). Succinic semialdehyde + TPN+ [long dash]*[center dot] succinate + TPNH + H+(2).