Validation of the Framingham Coronary Heart Disease Prediction Scores

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Open Access

11 July 2001

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 286 (2) , 180-187
https://doi.org/10.1001/jama.286.2.180

Abstract

The Framingham Heart Study has developed mathematical functions for predicting risk of clinical coronary heart disease (CHD) events.¹^-5 These are derived multivariable mathematical functions that assign weights to major CHD risk factors such as sex, age, blood pressure, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), smoking behavior, and diabetes status. For a person free of cardiovascular disease, his/her CHD risk factors are entered into the function to produce a probability estimate of developing CHD within a certain time period (eg, the next 5 years). Recently, Framingham investigators developed a simplified model that incorporates blood pressure and cholesterol categories proposed by the Fifth Joint National Committee on Hypertension (JNC-V) and the National Cholesterol Education Program, Adult Treatment Panel II (NCEP-ATP II).⁵^-8

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Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
JAMA, 2001