Synthesis ofp-(1-Adamantyl)- andp-(3-Substituted-1-Adamantyl)calix[4]arenes

Abstract
The direct alkylation of unsubstituted calix[4]arene 1 with various 1-hydroxyadamantanes 2 (3-R-1-HOAd, where R = H, n-Pr, i-Pr) in trifluoroacetic acid is proposed as a convenient synthesis of upper rim adamantyl substituted calix[4]arenes 3.

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