A New Technique for Investigating the Process of Tablet Compression: A Preliminary Report
- 1 September 1963
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1) , 413-421
- https://doi.org/10.1111/j.2042-7158.1963.tb12808.x
Abstract
This preliminary report covers static tests involving the incorporation of an electrical conducting material in a tablet formula and subsequent recording during compression of the change in electrical resistance of the compact. An assessment of the experimental variables has indicated optimum conditions for making dynamic tests on an instrumented tablet machine and suggested more refined adaptations of the technique. Comparisons between this electrical property of the material and other properties such as relative volume, initial granule size, moisture content of the granules and crushing strength of the compact are presented. The resistance plots show evidence of change in the physical condition of the material under pressure; that is an initial packing stage followed by a brief period during which the granular structure is capable of supporting the imposed load without breakdown and finally gradual failure of the granules to give a compact mass.Keywords
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