Evaluation of parametric and nonparametric two one-sided tests procedures for assessing bioequivalence of average bioavailability
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Journal of Biopharmaceutical Statistics
- Vol. 3 (1) , 85-102
- https://doi.org/10.1080/10543409308835050
Abstract
A simulation study was conducted to compare the levels of significance and power between Schuirmann's and nonparametric two one-sided tests procedures for a 2 ×2 crossover design under different combinations of sample sizes, intrasubject variabilities, and underlying distributions. Empirical results suggest that Schuirmann's two one-sided tests procedure is robust to minor departure from the assumption of normality.Keywords
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