Pulmonary Vascular Effects of Moderate and Severe Hypoxia in the Dog

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Abstract
Measurements made on 11 dogs under nembutal anesthesia, breathing 10% O2, in N2 and 5% O2 in N2 showed an average increase in pulmonary arterial pressure over control values breathing air of 48% and 62%, respectively. Pressures were measured through a Goodale-Lubin catheter in the pulmonary conus. Cardiac output, determined by a radio-active isotope dilution technique, increased an average of 6% and 15%, respectively. "Pulmonary" blood volume, as calculated from the dilution curve by the method of Ebert, was 115% of control with 10% O2 and 123% of control with 5% 02. The progressive alterations in pulmonary vascular pressure-flow relationships with decreasing inspired O2 tensions are interpreted as indicating increasing pulmonary vasoconstriction, in agreement with previously reported experiments in which the cardiac output was determined by the Fick procedure.

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