Kinetics of the Effect of Vincristine Sulfate on the Reproductive Integrity of Proliferating Cultured Leukemia L1210 Cells

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Abstract
When proliferating cultured L1210 cell populations were exposed to effective concentrations of VCR or colchicine, the kinetics of the reduction in the number of viable cells did not occur at a first-order rate (the fraction of cells killed per unit of time was not constant). The minimum effective concentration of VCR required to produce an effect on the reproductive integrity of L1210 populations was < 0.01 but > 0.001 μg/ml. If the duration of drug exposure was 24 hours, extensive cell killing could be produced by VCR concentrations which were relatively low when compared to the theoretical maximum concentration attainable in the body fluids of a mouse. The kinetics of the lethal action of VCR on proliferating cultured L1210 populations indicate that this agent has cell cycle specificity.

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