The Role of Calmodulin in Human Natural Killer Cell Activity
- 1 September 1983
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 18 (3) , 255-258
- https://doi.org/10.1111/j.1365-3083.1983.tb00865.x
Abstract
Calcium is known to play an essential role in the lytic mechanism of natural killer cells (NK), which form a subset of large granular lymphocytes. Many of the intracellular effects of calcium are mediated through the calcium‐binding protein calmodulin. In this study we have demonstrated that the specific calmodulin inhibitors (naphthalene‐sulphonamides) inhibit NK activity in humans at IC50's of 6.9 μM for W7 and 5.2 μM for W13. Comparison of the potency of these compounds with their less active counterparts suggests that NK activity is calmodulin‐dependent.Keywords
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