Sickle Hemoglobin Aggregation: A New Class of Inhibitors
- 10 June 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4295) , 1216-1219
- https://doi.org/10.1126/science.870976
Abstract
A number of tri- and tetrapeptides have been found to inhibit the aggregation and gelation of deoxygenated sickle cell hemoglobin. These inhibitors have hydrophobic phenylalanine residues at one end and hydrogen bonding lysine or arginine side chains at the other end. The backbone is not very specific. The inhibitors do not modify the oxygen carrying properties of hemoglobin. When the inhibitor and sickle hemoglobin are put inside reconstituted cells, the erythrocytes do not sickle upon deoxygenation. Compounds of this type may develop into useful agents in the therapy of sickle cell anemia.This publication has 20 references indexed in Scilit:
- New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acidNature, 1975
- Crystal structure of sickle-cell deoxyhemoglobin at 5 Å resolutionJournal of Molecular Biology, 1975
- Anti-sickling nature of dimethyl adipimidateBiochemical and Biophysical Research Communications, 1975
- Effect of Alkylureas on the Polymerization of Hemoglobin SProceedings of the National Academy of Sciences, 1974
- Effects of pH, 2,3-diphosphoglycerate and salts on gelation of sickle cell deoxyhemoglobinJournal of Molecular Biology, 1973
- Intermolecular Organization of Deoxygenated Sickle Haemoglobin determined by X-ray DiffractionNature, 1972
- Molecular Mechanism of Red Cell "Sickling"Science, 1966
- The Use of Esters of N-Hydroxysuccinimide in Peptide SynthesisJournal of the American Chemical Society, 1964
- Cleveland Abbe: A Pioneer American MeteorologistNature, 1956
- Sickle Cell Anemia, a Molecular DiseaseScience, 1949