Evoked noradrenaline release in the rabbit ear artery: enhancement by purines, attenuation by neuropeptide Y and lack of effect of calcitonin gene‐related peptide
Open Access
- 1 May 1994
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 112 (1) , 123-126
- https://doi.org/10.1111/j.1476-5381.1994.tb13040.x
Abstract
1 Adenosine (30 μm) and its analogues 5′-N-ethylcarboxaminoadenosine (5 and 30 μm) and l-phenylisopropyladenosine (5 and 30 μm), potentiated the evoked but not spontaneous release of tritiated noradrenaline in the rabbit central ear artery. 2 Prejunctional inhibition of the evoked but not spontaneous release of tritiated noradrenaline by 100 nm neuropeptide Y is greater at 2 min than at 10 min after superfusion of the peptide. 3 Calcitonin gene-related peptide (2.63 to 263 nm) did not affect the evoked or spontaneous release of tritiated noradrenaline in this preparation. 4 These results are discussed in terms of prejunctional modulation of sympathetic transmission in the rabbit central ear artery.Keywords
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