Syntheses of chlorpromazine undecahydrododecaborate and nonahydrodecaborate-promising agents for neutron capture therapy of malignant melanoma.

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Abstract
It was suggested by dermatologists that B compounds of chlorpromazine are promising agents for neutron capture therapy of malignant melanoma. The compounds should have a high B content, good stability and sufficient solubility in water. To fulfill these requirements, chlorpromazine undecahydrododecarborate and nonahydrodecaborate were synthesized from 2-chloro-10(3-bromopropyl)phenothiazine and ammonioundecahydrododecaborate or 2-ammoniononahydrodecaborate, respectively.