DEVELOPMENT OF ACUTE DYSTONIA AND TARDIVE-DYSKINESIA IN CEBUS MONKEYS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 25  (2) , 269-279
Abstract
In 4 out of 11 C. apella monkeys given haloperidol (0.05-1.0 mg/kg per day) orally for up to 35 mo. signs of tardive dyskinesia (TD) developed: 1 monkey developed barely noticeable TD after 4 mo., but showed marked and increasing symptoms of both generalized choreic and bucco-lingual TD after 8 mo. This animal died 3 mo. after discontinuation of haloperidol. At that time the signs of TD were still prominent. In another monkey bucco-lingual TD appeared after 3 mo. and was still reversible on discontinuation of haloperidol at 5 mo. After a further 12 mo. of haloperidol, the TD signs were long lasting, possibly irreversible, in this animal. A 3rd monkey showed slight and transient signs of TD at 14 mo., but following a further 20 mo. of haloperidol administration of choreiform syndrome became prominent after drug withdrawal. After 34 mo. a similar syndrome of choreic movements was noticed in another animal, increasing after withdrawal of haloperidol. The other 7 monkeys received haloperidol for 3-15 mo., without developing any signs of TD. Attacks of acute dystonia were noticed in all animals, sometimes necessitating anticholinergic medication [biperiden] or decreases in the daily haloperidol dose.

This publication has 2 references indexed in Scilit: