ANTITULARENSE SERUM: CORRELATION BETWEEN PROTECTIVE CAPACITY FOR WHITE RATS AND PRECIPITABLE ANTIBODY CONTENT
Open Access
- 1 July 1947
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 26 (4) , 756-760
- https://doi.org/10.1172/jci101858
Abstract
Protective antibody was demonstrated in 2-ml. quantities of each of 4 immune serums by intraperit. injn. of the 85- to 110-g. white rat, and by immediate subcut. challenge with 25 million viable organisms of maximal virulence, an average of 25,000 LD50 rat doses. Pre-challenge treatment with normal serums gave 95% mortality. Pre-treatment with immune serums of graded potency gave mortality rates ranging from 12.5% to 48% and these were inversely proportional to the precipitable antibody contents of the serums.Keywords
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