Katalysierende Wirkung von Cortison und anderen Nebennierenrindensteroiden auf die Autoxydation von Linolsäure in vitro

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Abstract
The effect of various corticosteroids on the oxidation of linoleic acid (1) was investigated and compared with that of various metal ions. Cortisone markedly accelerated the auto-oxidation of (1); this effect was detectable at 10-5 [image]. Hydro-cortisone, fluorohydrocortisone and 11-dehydrocorticosterone were about half as effective, while the effect of 17-hydroxy-ll-desoxy-corticosterone was barely detectable. Various other corticoids and all those esterified with acetic acid were inactive. In the "cortisone catalysis" approximately 3 atoms of O2 were consumed per mole of (1). The effect of small amounts of cortisone was accelerated by traces of Cu. Cu was the only metal with this activity, and the combined effect of cortisone and Cu exceeded their separate activities. The effect of cortisone as well as that of Cu was inhibited by complexone, and this inhibition was reversed by Cu. It is therefore assumed that cortisone acts by binding traces of Cu in the medium, to form a complex which is more active than Cu alone.

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