Some Effects of Relatively Low Levels of Eight Tablet Disintegrants on a Direct Compression System

Publisher Website
Google Scholar
Abstract
Eight common tablet disintegrants (Amberlite IRP-88, Corn Starch U.S.P. CLD, Explotab, Ac-Di-Sol, Sta-RX 1500 Starch, Polyplasdone XL, and Guar Gum) were used in concentrations of 0, 0.25, 0.5, 1 and 2% (w/w) in a direct compression system of 75:25 Unmilled Calcium Phosphate Dihydrate/Anhydrous Lactose. Using a Recording Powder Flowmeter (RPF) it was noticed that linearity of flow was relatively unaffected while g/sec. flow rate decreased with increasing concentrations. Each system was then lubricated and tableted keeping the applied pressure relatively constant. Evaluation of the resulting tablets showed that even at very low disintegrant concentrations, significant reduction in disintegration time took place. At the same time, very few detrimental effects often seen with tablet disintegrants, were noticed.

This publication has 4 references indexed in Scilit: