Increased calcitonin gene-related peptide- and cholecystokinin-like immunoreactivities in spinal motoneurones after dorsal rhizotomy
- 1 June 1992
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 88 (2) , 127-141
- https://doi.org/10.1007/bf01244818
Abstract
Possible changes in neuropeptides within the ventral horn of the spinal cord were investigated after unilateral dorsal rhizotomy at the lumbar level (L1–L6) in adult rats. Ten days after the surgery, immunohistochemical observations and radioimmunological determinations confirmed a marked loss of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivities within the superficial layers of the deafferented dorsal horn, as expected from the degeneration of primary afferent fibres containing these peptides. A concomitant increase in immunohistochemical staining and levels of CGRP (+296%) and CCK (+71%)- like immunoreactivities was observed in the ipsilateral ventral horn where both peptides are located in motoneurones. In contrast, substance P-like immunoreactivity that is confined to fibres and terminals within the ventral horn, was not altered by dorsal rhizotomy. These data indicate that the expression of neuropeptides in spinal motoneurones can be influenced by primary afferent inputs.Keywords
This publication has 47 references indexed in Scilit:
- Ultrastructural demonstration of synaptic connections between calcitonin gene-related peptide immunoreactive axons and dynorphin A(1–8) immunoreactive dorsal horn neurons in a rat model of peripheral inflammation and hyperalgesiaPeptides, 1990
- Increased staining of immunoreactive dynorphin cell bodies in the deafferented spinal cord of the ratNeuroscience Letters, 1988
- Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.The Journal of cell biology, 1987
- Calcitonin gene related peptide stimulates adenylate cyclase activity in rat striated muscleCellular and Molecular Life Sciences, 1987
- Does cholecystokinin-like immunoreactivity in rat primary sensory neurons represent calcitonin gene-related peptide?Neuroscience Letters, 1986
- Effect of Calcitonin Gene-Related Peptide on the Cyclic AMP Level of Isolated Mouse DiaphragmThe Japanese Journal of Pharmacology, 1986
- Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurons and sensory ganglia of the ratPeptides, 1985
- Immunocytochemical localization of substance P in the rat spinal cord with special reference to fibers within the ventral column of the rostral lumbar segmentsNeuroscience Letters, 1985
- Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processingNature, 1983
- The morphological relationships between substance P immunoreactive processes and ventral horn neurons in the human and monkey spinal cordJournal of Comparative Neurology, 1982