HIGH-DENSITY LIPOPROTEINS AND HEPATIC MICROSOMAL-ENZYME INDUCTION IN ALCOHOL CONSUMERS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 37  (1) , 91-96
Abstract
Plasma HDL [high density lipoprotein] cholesterol (HDL-C) and major apolipoproteins, A-I (A-I) and A-II (A-II), and indices of hepatic microsomal function, liver cytochrome P-450 (P-450) and plasma antipyrine clearance rate (AP-CL), in 8 alcohol consumers and 8 non-drinkers were compared. Alcohol consumers had increased P-450 and AP-CL showing an induction of hepatic microsomal function, and elevated HDL-C, A-I and A-II as compared with values in non-drinkers. Liver cytochrome P-450 concentrations were directly proportional to plasma HDL-C (r = 0.732, P < 0.01) and A-I (r = 0.564, P < 0.05) levels. These data suggest that alcohol by inducing liver microsomal function increases plasma HDL and favorably alters one of the risk factors of coronary heart disease.