Effect of α- and β-Adrenergic Blocking Agents on the Increase in Renin Secretion Produced by Stimulation of the Medulla Oblongata in Dogs

Publisher Website
Google Scholar
Abstract
The α-adrenergic blocking agent, phenoxybenzamine, was found to have no effect on the increase in renin secretion produced by stimulation of the ‘pressor area’ of the medulla oblongata in dogs. The β-adrenergic blocking agent, propranolol, reduced the response when administered at two different dose levels. Administration of propranolol plus phenoxybenzamine completely abolished the increase. The data are consistent with the hypothesis that renin secretion is controlled, at least in part, by β-adrenergic receptors in the kidney.

This publication has 0 references indexed in Scilit: