Supressor Cells in the Graft vs Host Reaction
Open Access
- 1 August 1973
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 111 (2) , 650-651
- https://doi.org/10.4049/jimmunol.111.2.650
Abstract
The importance of cellular interaction in the regulation of the immune response has become apparent in recent years. The first example of such interaction to be observed was synergy between bone marrow and thymus cells in the antibody response to sheep erythrocytes (1). Subsequently, two subpopulations of thymicderived (T)1 cells have been shown to cooperate positively in cellular immune responses such as graft-vs-host disease (GVH) (2, 3) and allograft rejection (4). A negative or inhibitory interaction has recently been described in humoral immunity (5–8) mediated by “regulator” or “suppressor” T cells which interact with bone marrow-derived (B) cells to reduce the antibody response. The cell-mediated GVH reaction is reduced in the presence of antigenic competition (9). Evidence has been presented to implicate suppressor T cells or a product thereof as the cause of antigenic competition (10, 11). These and other observations (12) suggest that the GVH reaction might be inhibited by suppressor T cells.Keywords
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