The Effect of Chronic Alcohol Intake Upon the Hepatic Microsomal Carcinogen-activation System
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 35 (4) , 168-170
- https://doi.org/10.1159/000225278
Abstract
Ethanol was administered to mice by repeated i.p. injection, or orally in the drinking water over an extended period of time. Following i.p. ethanol pretreatment further groups of mice received an injection of benzo(a)pyrene. Alcohol intake decreased the level of microsomal aryl hydrocarbon hydroxylase which corresponded to the observed decrease in DNA binding of benzo(a)pyrene. The number of tumors which developed in the alcohol pretreated mice exceeded those of the control animals.This publication has 1 reference indexed in Scilit:
- Dna binding and its relationship to carcinogenesis by different polycyclic hydrocarbonsInternational Journal of Cancer, 1977