Intraovarian release of eggs in the rat after indomethacin treatment at pro-oestrus

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Abstract
After indomethacin treatment, ovulation was blocked in a number of animals and those that did ovulate had low numbers of oviducal eggs. Treatment at 10.00 h seemed to be more effective in preventing ovulation than treatment at 17.00 h. In the ovarian sections of the treated animals, eggs were frequently seen in follicles in which the granulosa cells had begun to luteinize and a clear stigma was usually present. The histological features of these luteinizing follicles or corpora lutea accessoria were identical to those of true corpora lutea in the ovaries of the control animals. Indomethacin inhibits ovulation, does not affect LH [luteinizing hormone] release, and acts at the ovary. The preovulatory release of FSH [follicle stimulating hormone] is unaffected. The histological observations suggest that indomethacin affects the ovarian mechanism of ovulation by inducing the release of eggs from the follicles through misplaced stigmata. The formation of stigmata indicates that indomethacin does not inhibit the enzymatic processes leading to the disintegration of the follicular wall before ovulation, but somehow affects the site of formation of the stigma.

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