Demonstration of -Oxidation and Acetoacetate Formation in a Mouse Hepatoma.
- 1 December 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 84 (3) , 586-588
- https://doi.org/10.3181/00379727-84-20720
Abstract
Slices of a transplanted mouse hepatoma. C954, oxidized octanoate-1-C14 to c14O2 and acetoacetate-l,3-C14. Isotopic acetoacetate accumulated in quantities approaching that recovered in respiratory CO2. The distribution of isotope in the ketone body is consistent with the view that the short-chain fatty acid was degraded by beta-oxidation, the resulting C2 fragments condensing to form acetoacetate as well as being oxidized to CO2.Keywords
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