Reticulocyte membrane transferrin receptors
- 1 May 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 58 (5) , 418-426
- https://doi.org/10.1139/o80-055
Abstract
A membrane protein with specific transferrin binding activity has been isolated from rabbit reticulocytes. The isolation procedure involved the immunoprecipitation by antibody to transferrin of transferrin-receptor complexes from reticulocyte membrane proteins which had been solubilized with nonionic detergent. Receptor dissociated from the antibody-transferrin-receptor complexes could bind transferrin saturably and reversibly. It migrated electrophoretically as a single band of glycoprotein with an estimated MW of approximately 180,000 which was reduced to around 93,000 following complete dissociation with dithiothreitol.Keywords
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