Oxygen Consumption of Unstimulated Gastric Mucosa in Relation to the Secretion of Hydrochloric Acid and The Number of Parietal Cells

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Abstract
Oxygen consumption (Q02 in [mu]l/mg h) was determined in gastric mucosal slices from 35 patients suffering from duodenal and gastric ulcers. The examination was performed simultaneously in 5 parallel slices with a modified Scholander respirometer. In resected stomach mucosal preparations a significant difference was found between the Q02 of slices from the corpus and pyloric region. A significant correlation was demonstrated between the Q02 of corpus mucosa and the number of SDH-active parietal cells per unit of mucosal surface. In 15 patients a significant correlation was found between the Q02 in biopsies from unstimulated gastric mucosa and the values of acid output following large doses of histamine.