Pressor effect of renin

Publisher Website
Google Scholar
Abstract
The pressor activity of renin administered intravenously at various rates and at various states of purity was measured and the effects of anesthesia, heparinization, and atropinization were investigated. Under all of these conditions, the blood pressure of normotensive and hypertensive dogs was elevated considerably throughout the period of infusion and for some time thereafter. The pressor activity of single doses of angiotensin and of renin was abolished and that of norepinephrine was inhibited, up to 85%, during the infusion of renin. The refractory state (socalled tachyphylaxis) to renin is not specific, since the continuous infusion of methoxamine likewise abolished the pressor activity of superimposed single doses of renin or angiotensin. At a very high rate of infusion, renin caused two exceptional and highly abnormal effects, the return of the blood pressure to the base line during the infusion, and the failure of the infused renin to inhibit the pressor action of single doses of norepinephrine.

This publication has 1 reference indexed in Scilit: