B-Cell Activating Properties of Polymyxin B

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Abstract
Polymyxins are known to be inhibitors of certain polyclonal B cell activators such as lipopolysac‐charide and dextransulphate. However, increased specific responses to hapten‐coupled mitogens have been reported after the addition of polymyxins to superoptimal conjugate doses. In this paper we have studied the effect of polymyxin B on superoptimal polyclonal doses of lipoporysaccharide. Results similar to those reported for hapten‐lipopolysaccharide conjugates were obtained. Polymyxin B was also found to exert adjuvant properties for a primary immune response to sheep erythrocytes and to be a thymus‐independent antigen.