Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog
Open Access
- 26 May 1998
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 95 (11) , 6403-6407
- https://doi.org/10.1073/pnas.95.11.6403
Abstract
A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities. Evidence that the viral protein binds to human chemokine receptors was obtained by competition binding and calcium mobilization experiments. The broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged absence of an inflammatory response in skin tumors that harbor replicating molluscum contagiosum virus.Keywords
This publication has 40 references indexed in Scilit:
- Human Chemokines: An UpdateAnnual Review of Immunology, 1997
- Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHVScience, 1996
- The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 IsolatesPublished by Elsevier ,1996
- CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1Science, 1996
- Identification of a major co-receptor for primary isolates of HIV-1Nature, 1996
- A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion CofactorsCell, 1996
- HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorScience, 1996
- A Molecular Switch of Chemokine Receptor SelectivityPublished by Elsevier ,1996
- Monocyte Chemoattractant Protein-3 Is a Functional Ligand for CC Chemokine Receptors 1 and 2BPublished by Elsevier ,1995
- Mutation of Leu25 and Val27 Introduces CC Chemokine Activity into Interleukin-8Published by Elsevier ,1995