Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients
Open Access
- 1 June 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 40 (6) , 715-716
- https://doi.org/10.1093/rheumatology/40.6.715
Abstract
Sir, We read with interest the article by Griffith et al [1]. about whether patients with rheumatoid arthritis (RA) who are established on methotrexate (MTX) and folic acid 5 mg daily need to continue folic acid supplements in the long term. We concur fully with their conclusion that it is important to continue folic acid supplementation to encourage compliance due to the reduced incidence of side‐effects. However, we would also suggest that modulation of homocysteine levels is another, possibly more important, reason for continuing folic acid supplementation in RA patients treated with MTX.Keywords
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