Tumor Necrosis Factor Alpha Plays a Role in the Acceleration of Atherosclerosis byChlamydia pneumoniaein Mice
Open Access
- 1 May 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (5) , 3164-3165
- https://doi.org/10.1128/iai.73.5.3164-3165.2005
Abstract
The role of tumor necrosis factor alpha (TNF-α) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-α p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-α plays a role in the acceleration of atherosclerosis by C. pneumoniae.Keywords
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