The first untranslated exon of the human tenascin‐C gene plays a regulatory role in gene transcription
- 7 August 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 369 (2-3) , 335-339
- https://doi.org/10.1016/0014-5793(95)00778-8
Abstract
The transcription of the human tenacin‐C (TN‐C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp‐long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the human TN‐C gene promoter, while bases from 79 to 179 significantly reduce this activation.Keywords
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