Pressure-induced striatal dopamine release correlates hyperlocomotor activity in rats exposed to high pressure
- 1 August 1991
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 71 (2) , 638-643
- https://doi.org/10.1152/jappl.1991.71.2.638
Abstract
Free-moving rats chronically implanted in the striatum with multifiber carbon electrodes selective to dopamine were compressed in a helium-oxygen mixture to 80 bars. Extracellular dopamine level and behavioral symptoms of high-pressure neurological syndrome were simultaneously recorded. Under these conditions, the extracellular level of dopamine monitored by differential pulse voltammetry was found to be pressure dependent, and hyperlocomotor activity, a behavioral symptom of high-pressure neurological syndrome, was found to be linked to these pressure-induced changes in dopamine release.Keywords
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