Lipoprotein‐related coronary risk factors in patients with angiographically defined coronary artery disease: relation to number of stenosed arteries

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Abstract
To determine whether an index estimating antagonism between low density lipoprotein (LDL) and high density lipoprotein (HDL) would improve separation between groups with and without coronary atherosclerosis, patients undergoing coronary catheterization (35 women and 99 men) were analysed for total cholesterol (TC), HDL cholesterol (HDLc), apolipoprotein A (apo A) and apolipoprotein B (apo B). The subjects were categorized as groups 0, 1, 2 or 3 according to the number of stenosed arteries (> 75% areas stenosis). Thirty of the patients showed no significant coronary atherosclerosis (group 0). Serum apo B concentrations were directly related to the number of stenosed vessels, whereas the concentration of apo A and HDLc were negatively correlated with the number of stenosed arteries. An ''atherogenic Index'' (ATH index) calculated as the product of serum concentrations of apo B, and TC minus HDLc, divided by the product of apo A and HDLc, proved to be more satisfactory than individual lipoprotein components for discrimination between subjects with and without stenosis. Accordingly, identification of coronary groups may be improved by using the ATH index.