Human Recombinant Interleukin-lα Increases Elastase-Like Enzyme in Human Uterine Cervical Fibroblasts
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 30 (4) , 239-241
- https://doi.org/10.1159/000293277
Abstract
Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-lΑ stimulated cells to produce and secrete this elastase-like enzyme. These results suggest that modulation of this enzyme activity by interleukin-1 may play a significant role in the ripening and dilation of the cervix, because elastin is a component of the uterine cervix and its peptides are known to be chemotactic for leukocytes.Keywords
This publication has 0 references indexed in Scilit: