SURFACE-ANTIGENS ON MALIGNANT SEZARY AND T-CELL-CELLS CORRESPOND TO THOSE OF MATURE T-CELLS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (3) , 526-530
Abstract
Tumor cells from 8 adult patients with T cell chronic malignancies were investigated with a series of monoclonal antibodies recognizing T cell differentiation antigens. This series allowed definition of discrete subpopulations of mature T cells with functional specialization. All 6 patients with Sezary syndrome and 1 patient with T chronic lymphocytic leukemia had cells with the same phenotype as normal helper/inducer T cells; the other patient with T chronic lymphocytic leukemia had cells with the same phenotype as normal cytotoxic/suppressor T cells. Some clinical manifestations observed in these patients may reflect retention of functional activities by their malignant cells.