Enhancement of Host Susceptibility to Staphylococcus aureus Infection by Chronic Ethanol Ingestion–Modification by Glucan Immunostimulation

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Abstract
The susceptibility of chronic ethanol-treated mice to S. aureus infection was ascertained, as was the ability of the immunostimulant glucan to modify ethanol-induced susceptibility to infection. Chronic alcohol-treated mice showed enhanced sensitivity to S. aureus. The administration of glucan significantly prolonged survival in S. aureus infected control and chronic ethanol mice.