Benzodiazepine Receptors in the Human Fetus

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Abstract
The existence of benzodiazepine receptors in the human fetal brain, liver and placenta has been studied. At 12–15 weeks of gestation specific binding to fetal brain occurs. The dissociation constant of [3H]-flunitrazepam-specific binding was 1.5–2 nM and the maximum number of binding sites was 2.3–3.8 fmol/mg of total brain tissue. In the fetal liver and placenta some specific binding exists, yet the nonspecific binding is more extensive.